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Evidence is increasing that every addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both after they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err along the side of caution and permit the FDA do its job and demand some research be done so the public recognizes the side effects and risks of the medications before we bring them. Keep in mind that drug companies are in business to make money and that they would say everything to keep people on their own medications.

Researchers discovered that participants investing in this drug for a year, lost excess weight within four weeks and have kept the load off throughout the 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of more than one active ingredient, which might make them more efficient and safer.

Combo-pilling could be the newest fad or also the newest into the future under scrutiny and thus it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular could be the fact that as of right now there are no long term prescription diet pills that have been authorized by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise blood pressure levels and pulse rate, and mustn't be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must not used in patients with uncontrolled high hypertension, and also by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.


New UCLA study on smokers with mental, drug, and alcohol problems